Anti-SPAG16 Antibodies in Multiple Sclerosis
نویسندگان
چکیده
Multiple sclerosis is a chronic inflammatory disease of the central nervous system (CNS), characterized by myelin loss, axonal pathology and progressive neurodegeneration [1]. Disease starts in 85% of cases with a clinically isolated syndrome (CIS), a first (sub)acute neurological event with demyelination. Different clinical subtypes of MS exist, with 85-90% of patients experiencing relapsingremitting (RR) disease in which clinical relapses alternate with remission [2]. About 40% of RR-MS patients develop secondary progressive (SP) MS with progressive neurological disease. In 10-20% of patients, MS manifests as a primary progressive (PP) disease with a progressive course from the onset [2].
منابع مشابه
Sperm-associated antigen 16 is a novel target of the humoral autoimmune response in multiple sclerosis.
We have previously identified eight novel autoantibody targets in the cerebrospinal fluid of multiple sclerosis (MS) patients, including sperm-associated Ag 16 (SPAG16). In the current study, we further investigated the autoantibody response against SPAG16-a protein with unknown function in the CNS-and its expression in MS pathology. Using isoelectric focusing, we detected SPAG16-specific oligo...
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